Ontology highlight
ABSTRACT:
SUBMITTER: Cheng ZF
PROVIDER: S-EPMC7889824 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Biochemistry and biophysics reports 20210203
Natural killer (NK) cells, as a potential source for off-the-shelf cell therapy, attack tumor cells with low risk of severe cytokine release syndrome (CRS) or graft-versus-host disease (GvHD). Fcγ receptor IIIA, also known as CD16, further confers NK cells with antibody-dependent cell-mediated cytotoxicity (ADCC), one mechanism of action of antibody-based immunotherapy. Here, we establish a novel human NK cell line, oNK-1, endogenously expressing CD16 along with high levels of NK activation mark ...[more]