A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy.

ABSTRACT: The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the benefits of immune checkpoint therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting and enables dynamic tracking of immune toxicities in cancer patients receiving immune checkpoint inhibitor treatment - broader applications are anticipated in other disease indications. By analysing four prospective cytokine biomarkers that initiate inflammatory responses, the digital nanopillar SERS assay achieves both highly specific and highly sensitive

SUBMITTER: Li J 

PROVIDER: S-EPMC7889912 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature