Bedside functional monitoring of the dynamic brain connectivity in human neonates.

ABSTRACT: Clinicians have long been interested in functional brain monitoring, as reversible functional losses often precedes observable irreversible structural insults. By characterizing neonatal functional cerebral networks, resting-state functional connectivity is envisioned to provide early markers of cognitive impairments. Here we present a pioneering bedside deep brain resting-state functional connectivity imaging at 250-μm resolution on human neonates using functional ultrasound. Signal correlations between cerebral regions unveil interhemispheric connectivity in very preterm newborns. Furthermore, fine-grain correlations between homologous pixels are consistent with white/grey matter organization. Finally, dynamic resting-state connectivity reveals a significant occurrence decrease of thalam

SUBMITTER: Baranger J 

PROVIDER: S-EPMC7889933 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature