Prevalent Synergy and Antagonism Among Antibiotics and Biocides in Pseudomonas aeruginosa.

ABSTRACT: Antimicrobials can exert specific physiological effects when used in combination that are different from those when applied alone. While combination effects have been extensively mapped for antibiotic-antibiotic combinations, the combination effects of antibiotics with antimicrobials used as biocides or antiseptics have not been systematically investigated. Here, we investigated the effects of combinations of antibiotics (meropenem, gentamicin, and ciprofloxacin) and substances used as biocides or antiseptics [octenidine, benzalkonium chloride, cetrimonium bromide, chlorhexidine, Povidone-iodine, silver nitrate (AgNO₃), and Ag-nanoparticles] on the planktonic growth rate of Pseudomonas aeruginosa. Combination effects were investigated in growth experiments in microtiter p

SUBMITTER: Pietsch F 

PROVIDER: S-EPMC7889964 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature