Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease.

ABSTRACT: Increasing evidence suggests that gut dysbiosis plays vital roles in a variety of gut-brain disorders, such as Alzheimer's disease (AD). However, alterations of the gut microbiota as well as their correlations with cognitive scores and host immunity have remained unclear in well-controlled trials on Chinese AD patients. In this study, samples from 100 AD patients, and 71 age- and gender-matched, cognitively normal controls were obtained to explore the structural and functional alterations of the fecal microbiota targeting the V3-V4 region of the 16S rRNA gene by MiSeq sequencing, and to analyze their associations with clinical characteristics. Our data demonstrated a remarkably reduction in the bacterial diversity and alterations in the taxonomic composition of the fecal microbiota of the

SUBMITTER: Ling Z 

PROVIDER: S-EPMC7889981 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature