A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Ontology highlight
ABSTRACT:
SUBMITTER: Coignard J
PROVIDER: S-EPMC7890067 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Coignard Juliette J Lush Michael M Beesley Jonathan J O'Mara Tracy A TA Dennis Joe J Tyrer Jonathan P JP Barnes Daniel R DR McGuffog Lesley L Leslie Goska G Bolla Manjeet K MK Adank Muriel A MA Agata Simona S Ahearn Thomas T Aittomäki Kristiina K Andrulis Irene L IL Anton-Culver Hoda H Arndt Volker V Arnold Norbert N Aronson Kristan J KJ Arun Banu K BK Augustinsson Annelie A Azzollini Jacopo J Barrowdale Daniel D Baynes Caroline C Becher Heiko H Bermisheva Marina M Bernstein Leslie L Białkowska Katarzyna K Blomqvist Carl C Bojesen Stig E SE Bonanni Bernardo B Borg Ake A Brauch Hiltrud H Brenner Hermann H Burwinkel Barbara B Buys Saundra S SS Caldés Trinidad T Caligo Maria A MA Campa Daniele D Carter Brian D BD Castelao Jose E JE Chang-Claude Jenny J Chanock Stephen J SJ Chung Wendy K WK Claes Kathleen B M KBM Clarke Christine L CL Collée J Margriet JM Conroy Don M DM Czene Kamila K Daly Mary B MB Devilee Peter P Diez Orland O Ding Yuan Chun YC Domchek Susan M SM Dörk Thilo T Dos-Santos-Silva Isabel I Dunning Alison M AM Dwek Miriam M Eccles Diana M DM Eliassen A Heather AH Engel Christoph C Eriksson Mikael M Evans D Gareth DG Fasching Peter A PA Flyger Henrik H Fostira Florentia F Friedman Eitan E Fritschi Lin L Frost Debra D Gago-Dominguez Manuela M Gapstur Susan M SM Garber Judy J Garcia-Barberan Vanesa V García-Closas Montserrat M García-Sáenz José A JA Gaudet Mia M MM Gayther Simon A SA Gehrig Andrea A Georgoulias Vassilios V Giles Graham G GG Godwin Andrew K AK Goldberg Mark S MS Goldgar David E DE González-Neira Anna A Greene Mark H MH Guénel Pascal P Haeberle Lothar L Hahnen Eric E Haiman Christopher A CA Håkansson Niclas N Hall Per P Hamann Ute U Harrington Patricia A PA Hart Steven N SN He Wei W Hogervorst Frans B L FBL Hollestelle Antoinette A Hopper John L JL Horcasitas Darling J DJ Hulick Peter J PJ Hunter David J DJ Imyanitov Evgeny N EN Jager Agnes A Jakubowska Anna A James Paul A PA Jensen Uffe Birk UB John Esther M EM Jones Michael E ME Kaaks Rudolf R Kapoor Pooja Middha PM Karlan Beth Y BY Keeman Renske R Khusnutdinova Elza E Kiiski Johanna I JI Ko Yon-Dschun YD Kosma Veli-Matti VM Kraft Peter P Kurian Allison W AW Laitman Yael Y Lambrechts Diether D Le Marchand Loic L Lester Jenny J Lesueur Fabienne F Lindstrom Tricia T Lopez-Fernández Adria A Loud Jennifer T JT Luccarini Craig C Mannermaa Arto A Manoukian Siranoush S Margolin Sara S Martens John W M JWM Mebirouk Noura N Meindl Alfons A Miller Austin A Milne Roger L RL Montagna Marco M Nathanson Katherine L KL Neuhausen Susan L SL Nevanlinna Heli H Nielsen Finn C FC O'Brien Katie M KM Olopade Olufunmilayo I OI Olson Janet E JE Olsson Håkan H Osorio Ana A Ottini Laura L Park-Simon Tjoung-Won TW Parsons Michael T MT Pedersen Inge Sokilde IS Peshkin Beth B Peterlongo Paolo P Peto Julian J Pharoah Paul D P PDP Phillips Kelly-Anne KA Polley Eric C EC Poppe Bruce B Presneau Nadege N Pujana Miquel Angel MA Punie Kevin K Radice Paolo P Rantala Johanna J Rashid Muhammad U MU Rennert Gad G Rennert Hedy S HS Robson Mark M Romero Atocha A Rossing Maria M Saloustros Emmanouil E Sandler Dale P DP Santella Regina R Scheuner Maren T MT Schmidt Marjanka K MK Schmidt Gunnar G Scott Christopher C Sharma Priyanka P Soucy Penny P Southey Melissa C MC Spinelli John J JJ Steinsnyder Zoe Z Stone Jennifer J Stoppa-Lyonnet Dominique D Swerdlow Anthony A Tamimi Rulla M RM Tapper William J WJ Taylor Jack A JA Terry Mary Beth MB Teulé Alex A Thull Darcy L DL Tischkowitz Marc M Toland Amanda E AE Torres Diana D Trainer Alison H AH Truong Thérèse T Tung Nadine N Vachon Celine M CM Vega Ana A Vijai Joseph J Wang Qin Q Wappenschmidt Barbara B Weinberg Clarice R CR Weitzel Jeffrey N JN Wendt Camilla C Wolk Alicja A Yadav Siddhartha S Yang Xiaohong R XR Yannoukakos Drakoulis D Zheng Wei W Ziogas Argyrios A Zorn Kristin K KK Park Sue K SK Thomassen Mads M Offit Kenneth K Schmutzler Rita K RK Couch Fergus J FJ Simard Jacques J Chenevix-Trench Georgia G Easton Douglas F DF Andrieu Nadine N Antoniou Antonis C AC
Nature communications 20210217 1
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population ...[more]
Similar Datasets
