Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes.

ABSTRACT:

Background

Chemotherapy is the first line of treatment for cancer patients. However, the side effects cause severe muscle atrophy or chemotherapy-induced cachexia. Previously, the NF-κB/MuRF1-dependent pathway was shown to induce chemotherapy-induced cachexia. We hypothesized that acute collateral toxic effects of chemotherapy on muscles might involve other unknown pathways promoting chemotherapy-induced muscle atrophy. In this study, we investigated differential effects of chemotherapeutic drugs and probed whether alternative molecular mechanisms lead to cachexia.

Methods

We employed mouse satellite stem cell-derived primary muscle cells and mouse C2C12 progenitor cell-derived differentiated myotubes as model systems to test the effect of drugs. The widely used chemotherape

SUBMITTER: Amrute-Nayak M 

PROVIDER: S-EPMC7890149 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature