Heart and neural crest derivative 2-induced preservation of sympathetic neurons attenuates sarcopenia with aging.

ABSTRACT:

Background

Sarcopenia, or age-dependent decline in muscle force and power, impairs mobility, increasing the risk of falls, institutionalization, co-morbidity, and premature death. The discovery of adrenoceptors, which mediate the effects of the sympathetic nervous system (SNS) neurotransmitter norepinephrine on specific tissues, sparked the development of sympathomimetics that have profound influence on skeletal muscle mass. However, chronic administration has serious side effects that preclude their use for muscle-wasting conditions. Interventions that can adjust neurotransmitter release to changing physiological demands depend on understanding how the SNS affects neuromuscular transmission, muscle motor innervation, and muscle mass.

Methods

We examined age-dependent expres

SUBMITTER: Rodrigues ACZ 

PROVIDER: S-EPMC7890150 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature