Inflammation-induced cholestasis in cancer cachexia.

ABSTRACT:

Background

Cancer cachexia is a debilitating metabolic syndrome contributing to cancer death. Organs other than the muscle may contribute to the pathogenesis of cancer cachexia. This work explores new mechanisms underlying hepatic alterations in cancer cachexia.

Methods

We used transcriptomics to reveal the hepatic gene expression profile in the colon carcinoma 26 cachectic mouse model. We performed bile acid, tissue mRNA, histological, biochemical, and western blot analyses. Two interventional studies were performed using a neutralizing interleukin 6 antibody and a bile acid sequestrant, cholestyramine. Our findings were evaluated in a cohort of 94 colorectal cancer patients with or without cachexia (43/51).

Results

In colon carcinoma 26 cachectic mice, we discovered

SUBMITTER: Thibaut MM 

PROVIDER: S-EPMC7890151 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature