Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis.

ABSTRACT:

Background & aims

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine and an important regulator of innate immune responses. We hypothesised that serum concentrations of MIF are associated with disease severity and outcome in patients with decompensated cirrhosis and acute-on-chronic liver failure (ACLF).

Methods

Circulating concentrations of MIF and its soluble receptor CD74 (sCD74) were determined in sera from 292 patients with acute decompensation of cirrhosis defined as new onset or worsening of ascites requiring hospitalisation. Of those, 78 (27%) had ACLF. Short-term mortality was assessed 90 days after inclusion.

Results

Although serum concentrations of MIF and sCD74 did not correlate with liver function parameters or ACLF, higher MIF (opti

SUBMITTER: Wirtz TH 

PROVIDER: S-EPMC7890204 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature