The hypothalamic-pituitary-gonadal axis controls muscle stem cell senescence through autophagosome clearance.

ABSTRACT:

Background

With organismal aging, the hypothalamic-pituitary-gonadal (HPG) activity gradually decreases, resulting in the systemic functional declines of the target tissues including skeletal muscles. Although the HPG axis plays an important role in health span, how the HPG axis systemically prevents functional aging is largely unknown.

Methods

We generated muscle stem cell (MuSC)-specific androgen receptor (Ar) and oestrogen receptor 2 (Esr2) double knockout (dKO) mice and pharmacologically inhibited (Antide) the HPG axis to mimic decreased serum levels of sex steroid hormones in aged mice. After short-term and long-term sex hormone signalling ablation, the MuSCs were functionally analysed, and their aging phenotypes were compared with those of geriatric mice (30-month-old)

SUBMITTER: Kim JH 

PROVIDER: S-EPMC7890269 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature