Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients　- Protocol for Proof-of-Concept Feasibility Trial.

ABSTRACT: Background: Atrial fibrosis and inflammation play important roles in perpetuating and initiating atrial fibrillation (AF). Although the fibrotic area can be visualized as a delayed enhancement area on late gadolinium enhancement magnetic resonance imaging (LGE-MRI), atrial inflammation has not yet been visualized on any imaging modality. We describe the protocol for a feasibility study to visualize atrial inflammation on positron emission tomography/MRI (PET/MRI). Methods and Results: This is a single-arm, prospective, open-label proof-of concept trial, involving AF patients after cryoballoon ablation (CBA). A total of 30 paroxysmal AF patients will be enrolled and undergo simultaneous PET/MRI for the assessment of regional ¹⁸F-fluorodeoxyglucose (<

SUBMITTER: Kiuchi K 

PROVIDER: S-EPMC7890275 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature