Eimeria bovis infections induce G₁ cell cycle arrest and a senescence-like phenotype in endothelial host cells.

ABSTRACT: Apicomplexan parasites are well-known to modulate their host cells at diverse functional levels. As such, apicomplexan-induced alteration of host cellular cell cycle was described and appeared dependent on both, parasite species and host cell type. As a striking evidence of species-specific reactions, we here show that Eimeria bovis drives primary bovine umbilical vein endothelial cells (BUVECs) into a senescence-like phenotype during merogony I. In line with senescence characteristics, E. bovis induces a phenotypic change in host cell nuclei being characterized by nucleolar fusion and heterochromatin-enriched peripheries. By fibrillarin staining we confirm nucleoli sizes to be increased and their number per nucleus to be reduced in E. bovis-infected BUVECs. Additionally, nuclei of E. bovi

SUBMITTER: Velasquez ZD 

PROVIDER: S-EPMC7890351 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature