Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial.

ABSTRACT:

Importance

The efficacy of vitamin D3 supplementation in coronavirus disease 2019 (COVID-19) remains unclear.

Objective

To investigate the effect of a single high dose of vitamin D3 on hospital length of stay in patients with COVID-19.

Design, setting, and participants

This was a multicenter, double-blind, randomized, placebo-controlled trial conducted in 2 sites in Sao Paulo, Brazil. The study included 240 hospitalized patients with COVID-19 who were moderately to severely ill at the time of enrollment from June 2, 2020, to August 27, 2020. The final follow-up was on October 7, 2020.

Interventions

Patients were randomly assigned to receive a single oral dose of 200 000 IU of vitamin D3 (n = 120) or placebo (n = 120).

Main outcomes and measures

The prima

SUBMITTER: Murai IH 

PROVIDER: S-EPMC7890452 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature