The interplay of blood flow and temperature in regional hyperthermia: a mathematical approach.

ABSTRACT: In recent decades, hyperthermia has been used to raise oxygenation levels in tumours undergoing other therapeutic modalities, of which radiotherapy is the most prominent one. It has been hypothesized that oxygenation increases would come from improved blood flow associated with vasodilation. However, no test has determined whether this is a relevant assumption or other mechanisms might be acting. Additionally, since hyperthermia and radiotherapy are not usually co-administered, the crucial question arises as to how temperature and perfusion in tumours will change during and after hyperthermia. Overall, it would seem necessary to find a research framework that clarifies the current knowledge, delimits the scope of the different effects and guides future research. Here, we propose a simple m

SUBMITTER: Bosque JJ 

PROVIDER: S-EPMC7890498 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature