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Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4⁺ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.

ABSTRACT: Helminthic infections modulate host immunity and may protect their hosts from developing immunological diseases like inflammatory bowel disease. Induction of regulatory T cells (Tregs) may be an important part of this protective process. Heligmosomoides polygyrus bakeri infection also promotes the production of the regulatory cytokines TGF-β and IL-10 in the gut. In the intestines, TGF-β helps induce regulatory T cells. This study used Foxp3/IL-10 double reporter mice to investigate the effect of TGF-β on the differentiation of colon and mesenteric lymph node-derived murine Foxp3^- IL-10^- CD4⁺ T cells into their regulatory phenotypes. Foxp3^- IL-10^- CD4⁺ T cells from H. polygyrus bakeri-infected mice, as opposed

SUBMITTER: Hang L

PROVIDER: S-EPMC7890536 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4⁺ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4⁺ T Cells, Which Allows TGF-β to Induce IL-10-Producing Regulatory T Cells That Block Colitis.