Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.

ABSTRACT:

Background

The association of circulating lipids with clinical outcomes of drug-resistant castration-resistant prostate cancer (DR-CRPC) is not fully understood. While it is known that increases in select lipids correlate to decreased survival, neither the mechanisms mediating these alterations nor the correlation of resistance to drug treatments is well characterized.

Methods

This gap-in-knowledge was addressed using in vitro models of non-cancerous, hormone-sensitive, CRPC and drug-resistant cell lines combined with quantitative LC-ESI-Orbitrap-MS (LC-ESI-MS/MS) lipidomic analysis and subsequent analysis such as Metaboanalyst and Lipid Pathway Enrichment Analysis (LIPEA).

Results

Several lipid regulatory pathways were identified that are associated with Docetaxel re

SUBMITTER: Ingram LM 

PROVIDER: S-EPMC7890620 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature