Characterization of the human skin resistome and identification of two microbiota cutotypes.

ABSTRACT:

Background

The human skin microbiota is considered to be essential for skin homeostasis and barrier function. Comprehensive analyses of its function would substantially benefit from a catalog of reference genes derived from metagenomic sequencing. The existing catalog for the human skin microbiome is based on samples from limited individuals from a single cohort on reference genomes, which limits the coverage of global skin microbiome diversity.

Results

In the present study, we have used shotgun metagenomics to newly sequence 822 skin samples from Han Chinese, which were subsequently combined with 538 previously sequenced North American samples to construct an integrated Human Skin Microbial Gene Catalog (iHSMGC). The iHSMGC comprised 10,930,638 genes with the detection of 4

SUBMITTER: Li Z 

PROVIDER: S-EPMC7890624 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature