Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice.

ABSTRACT:

Background

In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra. The penumbra can be salvaged by timely thrombolysis/thrombectomy, the only available acute stroke treatment to date, but is progressively destroyed by the expansion of infarction. The underlying mechanisms of progressive infarction are not fully understood.

Methods

To address mechanisms, mice underwent filament occlusion of the middle cerebral artery (MCAO) for up to 4 h. Infarct development was compared between mice treated with antigen-binding fragments (Fab) against the platelet surface molecules GPIb (p0p/B Fab) or rat immunoglobulin G (IgG) F

SUBMITTER: Schuhmann MK 

PROVIDER: S-EPMC7890632 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature