Empowering individual trait prediction using interactions for precision medicine.

ABSTRACT:

Background

One component of precision medicine is to construct prediction models with their predicitve ability as high as possible, e.g. to enable individual risk prediction. In genetic epidemiology, complex diseases like coronary artery disease, rheumatoid arthritis, and type 2 diabetes, have a polygenic basis and a common assumption is that biological and genetic features affect the outcome under consideration via interactions. In the case of omics data, the use of standard approaches such as generalized linear models may be suboptimal and machine learning methods are appealing to make individual predictions. However, most of these algorithms focus mostly on main or marginal effects of the single features in a dataset. On the other hand, the detection of interacting features is a

SUBMITTER: Gola D 

PROVIDER: S-EPMC7890638 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature