Review and assessment of poliovirus immunity and transmission: synthesis of knowledge gaps and identification of research needs.

ABSTRACT: With the intensifying global efforts to eradicate wild polioviruses, policymakers face complex decisions related to achieving eradication and managing posteradication risks. These decisions and the expanding use of inactivated poliovirus vaccine (IPV) trigger renewed interest in poliovirus immunity, particularly the role of mucosal immunity in the transmission of polioviruses. Sustained high population immunity to poliovirus transmission represents a key prerequisite to eradication, but poliovirus immunity and transmission remain poorly understood despite decades of studies. In April 2010, the U.S. Centers for Disease Control and Prevention convened an international group of experts on poliovirus immunology and virology to review the literature relevant for modeling poliovirus transmission

SUBMITTER: Duintjer Tebbens RJ 

PROVIDER: S-EPMC7890644 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature