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ABSTRACT: Summary
In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respective confirmatory pathways of drug action.Availability and implementation
COVID-KOP is freely accessible at https://covidkop.renci.org/. For code and instructions for the original ROBOKOP, see: https://github.com/NCATS-Gamma/robokop.
SUBMITTER: Korn D
PROVIDER: S-EPMC7890668 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Korn Daniel D Bobrowski Tesia T Li Michael M Kebede Yaphet Y Wang Patrick P Owen Phillips P Vaidya Gaurav G Muratov Eugene E Chirkova Rada R Bizon Chris C Tropsha Alexander A
Bioinformatics (Oxford, England) 20210501 4
<h4>Summary</h4>In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respe ...[more]