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COVID-KOP: integrating emerging COVID-19 data with the ROBOKOP database.


ABSTRACT:

Summary

In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respective confirmatory pathways of drug action.

Availability and implementation

COVID-KOP is freely accessible at https://covidkop.renci.org/. For code and instructions for the original ROBOKOP, see: https://github.com/NCATS-Gamma/robokop.

SUBMITTER: Korn D 

PROVIDER: S-EPMC7890668 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

COVID-KOP: integrating emerging COVID-19 data with the ROBOKOP database.

Korn Daniel D   Bobrowski Tesia T   Li Michael M   Kebede Yaphet Y   Wang Patrick P   Owen Phillips P   Vaidya Gaurav G   Muratov Eugene E   Chirkova Rada R   Bizon Chris C   Tropsha Alexander A  

Bioinformatics (Oxford, England) 20210501 4


<h4>Summary</h4>In response to the COVID-19 pandemic, we established COVID-KOP, a new knowledgebase integrating the existing Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP) biomedical knowledge graph with information from recent biomedical literature on COVID-19 annotated in the CORD-19 collection. COVID-KOP can be used effectively to generate new hypotheses concerning repurposing of known drugs and clinical drug candidates against COVID-19 by establishing respe  ...[more]

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