Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma.

ABSTRACT:

Background

Medulloblastoma (MB) comprises four subtypes of which group 3 MB are the most aggressive. Although overall survival for MB has improved, the outcome of group 3 MB remains dismal. C-MYC (MYC) amplification or MYC overexpression which characterizes group 3 MB is a strong negative prognostic factor and is frequently associated with metastases and relapses. We previously reported that MYC expression alone promotes highly aggressive MB phenotypes, in part via repression of thrombospondin-1 (TSP-1), a potent tumor suppressor.

Methods

In this study, we examined the potential role of TSP-1 and TSP-1 peptidomimetic ABT-898 in MYC-amplified human MB cell lines and two distinct murine models of MYC-driven group 3 MBs.

Results

We found that TSP-1 reconsti

SUBMITTER: Chan TSY 

PROVIDER: S-EPMC7890793 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature