Identification of four genes and biological characteristics of esophageal squamous cell carcinoma by integrated bioinformatics analysis.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) has become one of the most serious diseases affecting populations worldwide and is the primary subtype of esophageal cancer (EC). However, the molecular mechanisms governing the development of ESCC have not been fully elucidated.

Methods

The robust rank aggregation method was performed to identify the differentially expressed genes (DEGs) in six datasets (GSE17351, GSE20347, GSE23400, GSE26886, GSE38129 and GSE77861) from the Gene Expression Omnibus (GEO). The Search Tool for the Retrieval of Interacting Genes (STRING) database was utilized to extract four hub genes from the protein-protein interaction (PPI) network. Module analysis and disease free survival analysis of the four hub genes were performed by Cytoscape and GE

SUBMITTER: Song Y 

PROVIDER: S-EPMC7890804 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature