Latent Toxoplasma gondii infections are associated with elevated biomarkers of inflammation and vascular injury.

ABSTRACT:

Background

Toxoplasma gondii is a protozoan parasite that infects cats as definitive hosts and other warm-blooded animals including humans as intermediate hosts. It forms infectious cysts in the brain, muscle and other tissues establishing life-long latent infection. Approximately 10% of the US population is infected. While latent infections are largely asymptomatic, they are associated with neurological deficits and elevated risks of neuropsychiatric diseases.

Methods

This cross-sectional epidemiological study investigated associations of T. gondii infections with biomarkers of inflammation and vascular injury: soluble intercellular adhesion molecule 1 (ICAM-1), soluble vascular cell adhesion molecule 1 (VCAM-1), C-reactive protein (CRP), and serum amyloid A (SAA). Serum sa

SUBMITTER: Egorov AI 

PROVIDER: S-EPMC7890825 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature