Epidemiology of systemic sclerosis: a multi-database population-based study in Tuscany (Italy).

ABSTRACT:

Background

Systemic Sclerosis (SSc) is a chronic autoimmune disease with a complex pathogenesis that includes vascular injury, abnormal immune activation, and tissue fibrosis. We provided a complete epidemiological characterization of SSc in the Tuscany region (Italy), considering prevalence and incidence, survival, comorbidities and drug prescriptions, by using a multi-database population-based approach. Cases of SSc diagnosed between 1st January 2003 and 31st December 2017 among residents in Tuscany were collected from the population-based Rare Diseases Registry of Tuscany. All cases were linked to regional health and demographic databases to obtain information about vital statistics, principal causes of hospitalization, complications and comorbidities, and drug prescriptions.

SUBMITTER: Coi A 

PROVIDER: S-EPMC7890847 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature