DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death in most western countries in both, males and females, accounting for roughly 20-25% of all cancer deaths. For choosing the most appropriate therapy regimen a definite diagnosis is a prerequisite. However, histological characterization of bronchoscopic biopsies particularly with low tumor cell content is often challenging. Therefore, this study aims at (a) determining the value of DNA methylation analysis applied to specimens obtained by bronchoscopic biopsy for the diagnosis of lung cancer and (b) at comparing aberrantly CpG loci identified in bronchoscopic biopsy with those identified by analyzing surgical specimens.

Results

We report the HumanMethylation450-based DNA methylation analysis of paired samples

SUBMITTER: Goldmann T 

PROVIDER: S-EPMC7890863 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature