Genetic epidemiological characteristics of a Hungarian subpopulation of patients with Huntington's disease.

ABSTRACT:

Background

Recent advances in therapeutic options may prevent deterioration related to Huntington's disease (HD), even at the pre-symptomatic stage. Be that as it may, a well-characterized patient population is essential for screening and monitoring outcome. Accordingly, the aim of this study was to describe the characteristics of a Hungarian subpopulation of HD patients and mutation carriers diagnosed at the University of Szeged.

Methods

We conducted a search for International Classification of Diseases (ICD) code G10H0 in the local medical database for the period of 1 January 1998 to 31 December 2018.

Results

We identified 90 HD cases (male: 45, female: 45) and 34 asymptomatic carriers (male: 15, female: 19). The median age of onset was 45 years (range: 16-79). Ther

SUBMITTER: Despotov K 

PROVIDER: S-EPMC7890867 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature