Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation.

ABSTRACT:

Background

Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are commonly used new-generation drugs for depression. Depressive symptoms are thought to be closely related to neuroinflammation. In this study, we used up-to-date protocols of culture and stimulation and aimed to understand how astrocytes respond to the antidepressants.

Methods

Primary astrocytes were isolated and cultured using neurobasal-based serum-free medium. The cells were treated with a cytokine mixture comprising complement component 1q, tumor necrosis factor α, and interleukin 1α with or without pretreatments of antidepressants. Cell viability, phenotypes, inflammatory responses, and the underlying mechanisms were analyzed.

Results

All the SSR

SUBMITTER: He JH 

PROVIDER: S-EPMC7890881 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature