LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions.

ABSTRACT:

Background

To investigate the mechanisms driving regulatory evolution across tissues, we experimentally mapped promoters, enhancers, and gene expression in the liver, brain, muscle, and testis from ten diverse mammals.

Results

The regulatory landscape around genes included both tissue-shared and tissue-specific regulatory regions, where tissue-specific promoters and enhancers evolved most rapidly. Genomic regions switching between promoters and enhancers were more common across species, and less common across tissues within a single species. Long Interspersed Nuclear Elements (LINEs) played recurrent evolutionary roles: LINE L1s were associated with tissue-specific regulatory regions, whereas more ancient LINE L2s were associated with tissue-shared regulatory regions and wit

SUBMITTER: Roller M 

PROVIDER: S-EPMC7890895 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature