A signature of seven immune-related genes predicts overall survival in male gastric cancer patients.

ABSTRACT:

Background

Gastric cancer (GC) has a high mortality rate and is one of the most fatal malignant tumours. Male sex has been proven as an independent risk factor for GC. This study aimed to identify immune-related genes (IRGs) associated with the prognosis of male GC.

Methods

RNA sequencing and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed IRGs between male GC and normal tissues were identified by integrated bioinformatics analysis. Univariate and multivariate Cox regression analyses were applied to screen survival-associated IRGs. Then, GC patients were separated into high- and low-risk groups based on the median risk score. Furthermore, a nomogram was constructed based on the TCGA dataset. The prognostic value of the risk

SUBMITTER: Xu X 

PROVIDER: S-EPMC7891008 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature