Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis.

ABSTRACT:

Background

Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship.

Methods

We pooled data of 8686 COPD patients from 7 studies with a median length of 36-months of follow up. Using a longitudinal natural cubic spline regression model, we examined the dose-response relationship between body mass index (BMI) and the rate of decline in forced expiratory volume in one second (FEV₁) in patients with GOLD 1 and 2 disease, stratified by gender and adjusted for age, smoking status, and cohort effects.

Results

There was an inverse linear relationship between BMI and the rate of FEV₁ decline in GOLD Grades 1 and 2, which was modified

SUBMITTER: Chen W 

PROVIDER: S-EPMC7891012 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature