Magnetic resonance diffusion tensor imaging applied to rat model of contrast-induced acute kidney injury.

ABSTRACT:

Objectives

In this preclinical investigation, the feasibility of using diffusion tensor imaging (DTI) to study contrast-induced acute kidney injury (CIAKI) is explored, comparing radiographic outcomes with histopathologic and immunohistochemical findings after repeated animal exposures to iodinated contrast agent.

Materials and methods

Forty-five male wistar rats were allocated to three groups (n = 15 each), each receiving two separate injections 1 day apart: group 1 (iodixanol then saline); group 2 (iodixanol twice); and control group (saline twice). Five rats were then randomly selected from each group at three separate time points (1 h, 24 h, and 120 h) for magnetic resonance imaging (MRI). Upon MRI completion, the animals were sacrificed, examining renal tissue an

SUBMITTER: Wang B 

PROVIDER: S-EPMC7891085 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature