Identification the ferroptosis-related gene signature in patients with esophageal adenocarcinoma.

ABSTRACT:

Background

Ferroptosis is a recently recognized non-apoptotic cell death that is distinct from the apoptosis, necroptosis and pyroptosis. Considerable studies have demonstrated ferroptosis is involved in the biological process of various cancers. However, the role of ferroptosis in esophageal adenocarcinoma (EAC) remains unclear. This study aims to explore the ferroptosis-related genes (FRG) expression profiles and their prognostic values in EAC.

Methods

The FRG data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate cox regressions were used to identify the prognostic FRG, and the predictive ROC model was established using the independent risk factors. GO and KEGG enrichment analyses were performed to investiga

SUBMITTER: Zhu L 

PROVIDER: S-EPMC7891153 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature