Lotus leaf extract inhibits ER^- breast cancer cell migration and metastasis.

ABSTRACT:

Background

Patients with estrogen receptor negative (ER^-) breast cancer have poor prognosis due to high rates of metastasis. However, there is no effective treatment and drugs for ER^- breast cancer metastasis. Our purpose of this study was to evaluate the effect of lotus leaf alcohol extract (LAE) on the cell migration and metastasis of ER^- breast cancer.

Methods

The anti-migratory effect of LAE were analyzed in ER^- breast cancer cells including SK-BR-3, MDA-MB-231 and HCC1806 cell lines. Cell viability assay, wound-healing assay, RNA-sequence analysis and immunoblotting assay were used to evaluate the cytotoxicity and anti-migratory effect of LAE. To further investigate the inhibitory effect of LAE on metastasis in vivo, subcutane

SUBMITTER: Tong Y 

PROVIDER: S-EPMC7891157 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature