Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration.

ABSTRACT: Bisphenol S (BPS) is a component of polyether sulfone used in a variety of industrial applications and consumer products. We investigated the plasma toxicokinetic (TK) behavior of free (unconjugated parent) and total (parent and conjugated) BPS in rats and mice following a single gavage administration (34, 110, or 340 mg/kg). In male rats, BPS was rapidly absorbed with free BPS maximum concentration (C_max) reached at ≤2.27 h. Elimination of free BPS in male rats was dose-dependent with estimated half-lives of 5.77-11.9 h. C_max and area under the concentration versus time curve (AUC) increased with dose although the increase in AUC was more than dose proportional. In male rats, total BPS C_max was reached ≤2.77 h with both C_max (≥ 10-fold) and AUC

SUBMITTER: Waidyanatha S 

PROVIDER: S-EPMC7891184 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature