Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis.

ABSTRACT: Craniosynostosis results from premature fusion of the cranial suture(s), which contain mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with brain growth. Infants with craniosynostosis have skull dysmorphology, increased intracranial pressure, and complications such as neurocognitive impairment that compromise quality of life. Animal models recapitulating these phenotypes are lacking, hampering development of urgently needed innovative therapies. Here, we show that Twist1^+/- mice with craniosynostosis have increased intracranial pressure and neurocognitive behavioral abnormalities, recapitulating features of human Saethre-Chotzen syndrome. Using a biodegradable material combined with MSCs, we successfully regenerated a functional cranial sut

SUBMITTER: Yu M 

PROVIDER: S-EPMC7891303 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature