Prognostic models versus single risk factor approach in first-trimester selective screening for gestational diabetes mellitus: a prospective population-based multicentre cohort study.

ABSTRACT:

Objectives

To evaluate whether (1) first-trimester prognostic models for gestational diabetes mellitus (GDM) outperform the currently used single risk factor approach, and (2) a first-trimester random venous glucose measurement improves model performance.

Design

Prospective population-based multicentre cohort.

Setting

Thirty-one independent midwifery practices and six hospitals in the Netherlands.

Population

Women recruited before 14 weeks of gestation without pre-existing diabetes.

Methods

The single risk factor approach (presence of at least one risk factor: BMI ≥30 kg/m² , previous macrosomia, history of GDM, positive first-degree family history of diabetes, non-western ethnicity) was compared with the four best performing models in our pre

SUBMITTER: van Hoorn F 

PROVIDER: S-EPMC7891327 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature