Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment.

ABSTRACT:

Background and objective

The complement system is engaged in inflammatory reactions both in the periodontal pockets and in the periodontium itself, where it can mediate tissue destruction. The aim of this study was, first, to compare salivary levels of the total complement system protein C3 and its split product, fluid-phase C3c in patients with periodontitis and periodontally healthy controls. Next, to determine if C3 and C3c levels had biomarker potential in diagnosing and monitoring periodontitis and its treatment. We hypothesized that salivary levels of total C3 and the split product C3c associated with the severity of periodontitis and reflected decreased inflammatory activity after periodontal treatment.

Methods

At baseline, stimulated saliva samples were collected fro

SUBMITTER: Grande MA 

PROVIDER: S-EPMC7891408 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature