Cytokine profiles and clinical characteristics in primary Sjogren´s syndrome patient groups.

ABSTRACT:

Background

Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by a lymphocytic infiltrate in salivary glands driving to epithelial damage. The pSS patients present heterogenic clinical and serological characteristics. This heterogenicity could be due to the cytokine microenvironment. Cytokine levels have been analyzed and reported individually, showing controversial results; for that reason, we considered essential to evaluate a cluster of cytokines and relate them with antibody levels and clinical characteristics to find pSS subgroups.

Methods

Ninety-nine pSS patients, diagnosed by the 2016 ACR/EULAR classification criteria, and 76 control subjects (CS) were included. Cytokine quantification was performed by Multiplex assay. Principal component analysis

SUBMITTER: Lopez-Villalobos EF 

PROVIDER: S-EPMC7891511 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature