Association study of genetic variants at TTC32-WDR35 gene cluster with coronary artery disease in Chinese Han population.

ABSTRACT:

Background

TTC32-WDR35 gene cluster has been genome-wide significantly associated with coronary artery disease (CAD). However, the common variants in this region contributing to CAD risk remain elusive.

Methods

We performed a case-control study enrolling 935 CAD cases and 935 age-sex-frequency-matched controls from unrelated southwest Chinese Han population. Five variants were determined by TaqMan assay.

Results

This study indicated that rs721932 CG genotype was associated with CAD risk (OR = 0.68, 95% CI: 0.54-0.86; P = .001). Stratified analysis showed that the risk associated with rs12617744 AA genotype was robust in male (OR = 0.62, 95% CI: 0.42-0.93, P = .02). The gene dosage of the risk allele at rs12617744 showed a significant association with left circumflex a

SUBMITTER: Xu Y 

PROVIDER: S-EPMC7891520 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature