Optimal Estimate for Energy Requirements in Adult Patients With the m.3243A>G Mutation in Mitochondrial DNA.

ABSTRACT:

Aim

We aimed to identify the optimal method to estimate total energy expenditure (TEE) in mitochondrial disease (MD) patients.

Methods

Resting energy expenditure (REE) was measured in MD patients carrying the m3243A>G mutation using indirect calorimetry (IC) and compared with results of 21 predictive equations (PEs) for REE and with REE-IC measurements in healthy controls. Physical activity level (PAL) was measured using accelerometery (SenseWear) and compared with a fixed average PAL (1.4) as well as patients' self-estimated activity levels. TEE was calculated as REE-IC × PAL SenseWear and compared with usual care and energy recommendations for healthy adults.

Results

Thirty-eight MD patients (age: 48 ± 13 years; body mass index 24 ± 4 kg/m² ; male 20%) an

SUBMITTER: Zweers HEE 

PROVIDER: S-EPMC7891583 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature