Orthostatic Hypotension: A Prodromal Marker of Parkinson's Disease?

ABSTRACT:

Background

Orthostatic hypotension is common in patients with Parkinson's disease (PD). However, it remains unknown whether orthostatic hypotension is a marker of prodromal PD or more advanced disease. The objectives of this study were to assess whether orthostatic hypotension is a prodromal marker of PD in the general population.

Methods

This study was embedded in the Rotterdam Study, a large prospective population-based cohort in the Netherlands. We measured orthostatic hypotension in 6910 participants. First, we determined the relation between prevalent PD and orthostatic hypotension using logistic regression. Second, we followed PD-free participants for the occurrence of PD until 2016 and studied the association between orthostatic hypotension and the risk of PD using Co

SUBMITTER: Dommershuijsen LJ 

PROVIDER: S-EPMC7891584 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature