Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network.

ABSTRACT: Carotid artery atherosclerotic disease (CAAD) is a risk factor for stroke. We used a genome-wide association (GWAS) approach to discover genetic variants associated with CAAD in participants in the electronic Medical Records and Genomics (eMERGE) Network. We identified adult CAAD cases with unilateral or bilateral carotid artery stenosis and controls without evidence of stenosis from electronic health records at eight eMERGE sites. We performed GWAS with a model adjusting for age, sex, study site, and genetic principal components of ancestry. In eMERGE we found 1793 CAAD cases and 17,958 controls. Two loci reached genome-wide significance, on chr6 in LPA (rs10455872, odds ratio [OR] (95% confidence interval [CI]) = 1.50 (1.30-1.73), p = 2.1 × 10^-8 ) and on chr7, an intergenic si

SUBMITTER: Palmer MR 

PROVIDER: S-EPMC7891640 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature