Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants.

ABSTRACT:

Background

Glycolic acid (GA) is an effective way of reversing the signs of age and photodamage. GA enhances desquamation of the stratum corneum and induces biological responses that can help restore skin's integrity. GA can, however, cause irritation, especially when its concentration is high, and its pH is low. Thus, most commercially available products for home use contain relatively low GA concentrations and are partially neutralized to a pH around 4.

Aims

The aim of this study was to determine the biological effects and relative efficacy of cosmetic formulations containing GA at concentrations ranging from 8% to 25% at pH 4 in human ex vivo skin explants.

Methods

Human skin explants were topically treated with gel formulations and oil-in-water creams containing 8

SUBMITTER: Narda M 

PROVIDER: S-EPMC7891644 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature