Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations.

ABSTRACT: S. epidermidis is a substantial component of the human skin microbiota, but also one of the major causes of nosocomial infection in the context of implanted medical devices. We here aimed to advance the understanding of S. epidermidis genotypes and phenotypes conducive to infection establishment. Furthermore, we investigate the adaptation of individual clonal lines to the infection lifestyle based on the detailed analysis of individual S. epidermidis populations of 23 patients suffering from prosthetic joint infection. Analysis of invasive and colonizing S. epidermidis provided evidence that invasive S. epidermidis are characterized by infection-supporting phenotypes (e.g. increased biofilm formation, growth in nutrient poor media and antibiotic resistance), as well as specific genetic tra

SUBMITTER: Both A 

PROVIDER: S-EPMC7891712 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature