Genetically-determined body mass index and the risk of atrial fibrillation progression in men and women.

ABSTRACT:

Aims

Limited causal evidence is available on the relationship between body mass index (BMI) and atrial fibrillation (AF) progression. Sex differences have been noted and may be relevant for AF progression. We investigated the association between the BMI Genetic Risk Score (GRS) and AF progression in men and women of the Groningen Genetic Atrial Fibrillation (GGAF) cohort.

Methods and results

The GGAF cohort (n = 2207) is a composite of 5 prospective cohorts with individuals of European ancestry. AF patients with genetic information, with at least 12 months follow-up and AF progression data were included. AF progression was defined as progression from paroxysmal to persistent/permanent AF, or persistent to permanent AF. A BMI GRS was constructed of genetic variants associated

SUBMITTER: Siland JE 

PROVIDER: S-EPMC7891778 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature