Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.

ABSTRACT:

Study question

Is it possible to identify by mass spectrometry a wider range of proteins and key proteins involved in folliculogenesis and oocyte growth and development by studying follicular fluid (FF) from human small antral follicles (hSAF)?

Summary answer

The largest number of proteins currently reported in human FF was identified in this study analysing hSAF where several proteins showed a strong relationship with follicular developmental processes.

What is known already

Protein composition of human ovarian FF constitutes the microenvironment for oocyte development. Previous proteomics studies have analysed fluids from pre-ovulatory follicles, where large numbers of plasma constituents are transferred through the follicular basal membrane. This attenuates the det

SUBMITTER: Pla I 

PROVIDER: S-EPMC7891813 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature