Dioxin exposure associated with fecundability and infertility in mothers and daughters of Seveso, Italy.

ABSTRACT:

Study question

Is there an association between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and fecundability and infertility among Seveso women and their daughters?

Summary answer

TCDD exposure is associated with a decrease in fecundability and increased risk of infertility in women, as well as their daughters.

What is known already

In animal studies, maternal exposure to TCDD is associated with decreased fertility in offspring. Effects of TCDD are mediated by activation of the aryl hydrocarbon receptor (AHR) pathway.

Study design, size, duration

The Seveso Women's Health Study (SWHS) has followed 981 women exposed to TCDD in a 1976 accident since 1996. In 2014, we initiated the Seveso Second Generation Study to follow-up their children.

Participants

SUBMITTER: Eskenazi B 

PROVIDER: S-EPMC7891815 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature