Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR‑326/TAZ axis.

ABSTRACT: Circular RNA 0000511 (circ_0000511) has been observed to be dysregulated in breast cancer (BC). However, the functions of circ_0000511 in breast cancer remain unknown. The expression levels of circ_0000511, ribonuclease P RNA component H1, microRNA‑326 (miR‑326) and transcriptional co‑activator with PDZ‑binding motif (TAZ) were examined by reverse transcription‑quantitative PCR. Colony formation and MTT assays were conducted to analyze the cellular proliferative ability. The apoptotic rate was assessed by flow cytometry. Western blot analysis was used to evaluate the expression levels of B cell leukemia/lymphoma 2 (Bcl‑2), Bcl‑2 associated X apoptosis regulator, cleaved caspase‑3 and TAZ. Transwell assays were performed to evaluate the migration and invasion of BC cells. The target interac

SUBMITTER: Wu D 

PROVIDER: S-EPMC7891826 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature